Sequential medical trials

Sequential Medical Trials, 2nd Edition

morphology at the macroscopic, microscopic and ultrastructural levels. Wherever appropriate, he goes from structure into function and introduces concepts involving histochemistry, biochemistry, biophysics and bioengineering. The book is easy to read and presents the material in a very concise fashion and focuses upon the need for more extensive microcirculatory research. As an introduction to t...

Bias and Conditioning in Sequential Medical Trials

Randomized Controlled Trials (RCTs) are currently the gold standard within evidencebased medicine. Usually, they are conducted as sequential trials allowing for monitoring for early signs of effectiveness or harm. However, evidence from early stopped trials is often charged with being biased towards implausibly large effects (e.g., Bassler et al. 2010). To our mind, this skeptical attitude is u...

Some Developments in the Theory and Practice of Sequential Medical Trials

Bayesian Decision Theoretic Design for Group Sequential Medical Trials having Multivariate Patient Response

In the conduct of sequential clinical trials primary statistical issues include design, monitoring and reporting. Here we focus on design issues. Group sequential designs have been developed to link patient accrual to when interim analysis should occur. In practice, trials with multiple arms and multivariate patient response are important. We present an approach for implementing and assessing o...

Estimation in adaptive group sequential trials

2 Group Sequential Designs (GSD) 2 2.1 GST object . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.1.1 Alpha spending function (SF) . . . . . . . . . . . . . . . . 4 2.2 plan.GST example . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.3 Overall p-values for GSDs . . . . . . . . . . . . . . . . . . . . . . 6 2.3.1 Repeated p-values in a classical GSD . . . . . . . . . . . ...